LIRIC: Laser induced refractive index change

Clerio Vision’s LIRIC is a minimally invasive method to correct the eye’s aberrations with a laser. This is a [potential] paradigm shift in how we correct the eye’s refractive error. With all previous refractive surgery techniques, a laser such as an excimer or femtosecond is used to cut and ablate tissue. With LIRIC, a femtosecond laser is used at low energy levels, below the ablation threshold.




LIRIC is performed at a wavelength of 405 nm, which is at the blue end of the visible spectrum. At this wavelength, LIRIC is a 2-photon absorption process, resulting in highly localized refractive index changes. Within the laser focus volume (approximately 5–10 µm in diameter and length), instead of removing or disrupting tissue, we are altering collagen fibril density.1-3 LIRIC is relatively noninvasive in that we are using pulse energies that are 1/100th to 1/1,000th those used to create a femtosecond laser flap. During LIRIC, the laser alters the refractive index in a highly localized fashion—akin to using a fine-point pen.

LIRIC can be performed on IOLs, corneas, or contact lenses. The technology can also treat myopia, hyperopia, astigmatism, and higher-order aberrations in pseudophakes and in nonpseudophakes. In addition, LIRIC can treat a wide variety of refractive errors without relying on a particular IOL polymer or on pupillary dilation. LIRIC can be modified or repeated on multiple occasions because it changes the cornea only in a stromal layer that is 10 µm thick.



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